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yvrB [2017-8-11 16:0:3]
ABC transporter (ATP binding domain), similar to iron permease
product
ABC transporter (ATP binding domain)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.7|Uptake of cofactors][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.13|Biosynthesis/ acquisition of cobalamine (B12))][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
3,402,469 → 3,403,530
The protein
Structure
[PDB|4R9U], the ''E. coli'' BtuC-BtuD complex, BtuC shares 40% identity, 71% similarity with YvrB, [Pubmed|25402482]Expression and Regulation
Operons
genes
[gene|C76265F521D9A153F28AC6BACD935CC20DEA5D9C|yvrC]-[gene|1DC4A3D7E93677B0EAD15F43C80E50FD98527EBC|yvrB]-[gene|128EBAE9C14C7BB75173DF912853A6FCE86ABCE4|yvrA]-[gene|468D9141EAC78556C9F6C564875F70EC43E60C1C|yvqK]
regulatory mechanism
[regulon|B12 riboswitch|B12 riboswitch]: termination, upon binding of B12 [Pubmed|14704351], in [regulon|B12 riboswitch|B12 riboswitch]regulation
expression is decreased in the presence of cobalamin (vitamin B12) ([SW|B12 riboswitch]) [Pubmed|14704351]view in new tabBiological materials
Mutant
MGNA-B044 (yvrB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1043 NBRP B. subtilis, Japan]References
10092453,25402482,14704351